Electrocorticography-Based Real-Time Functional Mapping for Pediatric Epilepsy Surgery

Milena Korostenskaja; Kyousuke Kamada; Christoph Guger; Christine M. Salinas; Michael Westerveld; Eduardo M. Castillo; Elena Salillas; Po-Ching Chen; Elana Harris; Ian Seddon; Mohammed Elsayed; Christoph Kapeller; Alex Schaal; Joo-Hee Seo; James Baumgartner; Ki H. Lee

doi:10.1055/s-0035-1563728

Journal of Pediatric Epilepsy, Table of Contents

Journal of Pediatric Epilepsy 2015; 04(04): 184-206
DOI: 10.1055/s-0035-1563728

Review Article

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Electrocorticography-Based Real-Time Functional Mapping for Pediatric Epilepsy Surgery

Milena Korostenskaja

¹Milena's Functional Brain Mapping and Brain-Computer Interface Lab, Florida Hospital for Children, Orlando, Florida, United States

²MEG Lab, Florida Hospital, Orlando, Florida, United States

³Comprehensive Pediatric Epilepsy Center, Florida Hospital for Children, Orlando, Florida, United States

,

Kyousuke Kamada

⁴Department of Neurosurgery, Asahikawa Medical University, Hokkaido, Japan

,

Christoph Guger

⁵g.tec Medical Engineering GmbH, Graz, Austria

,

Christine M. Salinas

³Comprehensive Pediatric Epilepsy Center, Florida Hospital for Children, Orlando, Florida, United States

⁶Division of Neuropsychology, Florida Hospital for Children, Orlando, Florida, United States

,

Michael Westerveld

³Comprehensive Pediatric Epilepsy Center, Florida Hospital for Children, Orlando, Florida, United States

⁶Division of Neuropsychology, Florida Hospital for Children, Orlando, Florida, United States

,

Eduardo M. Castillo

²MEG Lab, Florida Hospital, Orlando, Florida, United States

³Comprehensive Pediatric Epilepsy Center, Florida Hospital for Children, Orlando, Florida, United States

,

Elena Salillas

⁷Basque Center on Cognition, Brain and Language, San Sebastian, Spain

,

Po-Ching Chen

¹Milena's Functional Brain Mapping and Brain-Computer Interface Lab, Florida Hospital for Children, Orlando, Florida, United States

³Comprehensive Pediatric Epilepsy Center, Florida Hospital for Children, Orlando, Florida, United States

,

Elana Harris

⁸Division of Child & Adolescent Psychiatry, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States

,

Ian Seddon

¹Milena's Functional Brain Mapping and Brain-Computer Interface Lab, Florida Hospital for Children, Orlando, Florida, United States

³Comprehensive Pediatric Epilepsy Center, Florida Hospital for Children, Orlando, Florida, United States

,

Mohammed Elsayed

¹Milena's Functional Brain Mapping and Brain-Computer Interface Lab, Florida Hospital for Children, Orlando, Florida, United States

³Comprehensive Pediatric Epilepsy Center, Florida Hospital for Children, Orlando, Florida, United States

,

Christoph Kapeller

⁵g.tec Medical Engineering GmbH, Graz, Austria

,

Alex Schaal

¹Milena's Functional Brain Mapping and Brain-Computer Interface Lab, Florida Hospital for Children, Orlando, Florida, United States

³Comprehensive Pediatric Epilepsy Center, Florida Hospital for Children, Orlando, Florida, United States

,

Joo-Hee Seo

³Comprehensive Pediatric Epilepsy Center, Florida Hospital for Children, Orlando, Florida, United States

,

James Baumgartner

³Comprehensive Pediatric Epilepsy Center, Florida Hospital for Children, Orlando, Florida, United States

,

Ki H. Lee

³Comprehensive Pediatric Epilepsy Center, Florida Hospital for Children, Orlando, Florida, United States

› Author Affiliations

Abstract

Precise localization of eloquent cortex in children may provide much needed surgical guidance and expand surgical epilepsy treatment options. It reduces the risk of postsurgical functional deficits and benefits children's quality of life, educational capacity, and long-term employment potential. The ultimate goal of functional mapping for pediatric epilepsy surgery is to decrease postsurgical functional morbidity. In this review article, we will discuss the electrocorticography (ECoG)-based real-time functional mapping (RTFM) technique for localizing motor-, somatosensory-, and language-specific regions. The examples demonstrating ECoG-based RTFM mapping techniques will be given from the data produced by the authors. We will demonstrate that the RTFM technique is a functional mapping tool based on direct measurement of neural activity that is time- and effort-effective, safe, well tolerated by children, and is expected to lead to reduced postsurgical functional morbidity in pediatric epilepsy patients. In conjunction with other utilized functional imaging modalities, RTFM may reduce cognitive morbidity and, as a consequence, benefit children's quality of life and educational capacity.

Keywords

electrocorticography - epilepsy - epilepsy surgery - functional magnetic resonance imaging - pediatrics - magnetoencephalography

Full Text

References

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